When you can lay claim to being one of the weirdest acts from New Orleans, that’s saying something. For years the duo of mad organist Quintron (Robert Rolston) and his wife, Panacea Pussycat, have been making wild, genre-defying noise rock and soul with self-made instruments — often from their own Ninth Ward club, the Spellcaster Lodge. Miss Pussycat is a talented puppeteer (Trixie and the Treetrunks) who plays maracas and sings. And Quintron even patented his own Drum Buddy instrument, a light-activated, analog synth used by artists as wide-ranging as Laurie Anderson and Fred Armisen of “Saturday Night Live.” These modern-day musical dadaists don’t so much give concerts as rain Technicolor freak outs — with a lot more inspiration and “play” than any newfangled creative conference from self-appointed online impresarios, that’s for sure. They’ll be joined by locals Bermuda Triangles and Nervous Ticks at Strange Matter on April 21, with doors open at 9 p.m. Tickets are $8 in advance, $10 at the show. strangematterrva.com.